Prison Break premiered in August 2005. The show was an immediate hit and followed Michael Scofield (Wentworth Miller) as he engineered a daring escape from Fox River Penitentiary to free his wrongly convicted brother Lincoln Burrows (Dominic Purcell) from Death Row. With the prison break a success, the brothers, along with six additional escapees, were part of a nationwide manhunt headed by FBI Agent Alex Mahone (William Fichtner), who later was revealed to be working for The Company, a shadowy government organization that had initially framed Lincoln.
The action then moved to Panama where the tables were turned and Lincoln worked to free Michael from the hellish prison SONA. After eventually escaping from Central America, the brothers teamed with Homeland Security Agent Don Self (Michael Rapaport) to dismantle The Company once and for all by stealing SCYLLA, a device that contained the organization's most valuable secrets. Following a series of double-crosses, the brothers now find themselves racing to retrieve SCYLLA, which unbeknownst to them has landed in the possession of their estranged mother and Company operative Christina (Kathleen Quinlan).